Table 3.

Effect estimates (odds ratios) for spina bifida-affected pregnancies associated with maternal choline intake, CHKA SNP hCV1562388 (A>C), hCV1562393(C>G), PCYT1A SNPs rs939883 (T>A) and rs3772109 (T>C) genotypes. Breslow-Day test: P > 0.05. Lower 25%: total choline intake ≤ 289.93 mg/day. Higher 75 %: total choline intake > 513.24 mg/day.

CHKA gene	Cases	Controls	OR	(95% CI)
SNP hCV1562388 (A>C)
Lower 25 percentile			Reference
AA	17	35
AC + CC	15	49	0.63	0.28–1.63
Higher 75 percentile			Reference
AA	37	103
AC + CC	31	148	0.58	0.34–1.00
SNP hCV1562393(C>G)
Lower 25 percentile			Reference
CC	22	58		-
CG + GG	9	25	1.08	0.43–2.70
Higher 75 percentile			Reference
CC	44	167		-
CG + GG	23	83	1.05	0.60–1.86
PCYT1A gene	Cases	Controls	OR	95% CI
SNP rs939883 (T>A)
Lower 25 percentile			Reference
TT	9	37
TA	17	35	1.23	0.43–3.52
AA	7	11	1.66	0.41–3.52
Higher 75 percentile			Reference
TT	26	95
TA	31	126	0.90	0.50–1.61
AA	12	27	1.62	0.72–3.64
SNP rs3772109 (T>C)
Lower 25 percentile			Reference
TT	9	27
TC	17	40	1.28	0.50–3.28
CC	5	16	0.94	0.27–3.29
Higher 75 percentile			Reference
TT	24	77
TC	34	124	0.88	0.49–1.59
CC	10	49	0.59	0.25–1.37