Table 1.
VEGF, soluble VEGF receptor Flt-1, and vWf in glaucoma compared to controls
| NTG | POAG | Controls | p Value | |
| Number | 26 | 24 | 26 | |
| Age (years) | 72.9 (10.2) | 75.1 (11.0) | 73.4 (9.2) | 0.744 |
| Median duration of known glaucoma (years) | 1.5 | 3.5 | … | 0.04 (Mann-Whitney test) |
| Past medical history (n) | ||||
| Hypertension (treated) | 7 | 13 | … | |
| Ischaemic heart disease | 5 | 5 | ||
| Cerebrovascular disease | 2 | 3 | ||
| Body mass index (kg/m2) | 25.5 (3.8) | 24.7 (4.5) | … | 0.53 (t-test) |
| Current smokers (n) | 3 | 1 | 3 | |
| Receiving treatment for glaucoma (n) | 14 | 20 | … | |
| Systolic BP (mm Hg) | 148.2 (21.6) | 150.5 (24.7) | 144.3 (28.0) | 0.694 |
| Diastolic BP (mm Hg) | 84 (7.3) | 86.7 (13.8) | 79.8 (7.4) | 0.051 |
| % with blood pressure >160/90 mm Hg | 31% | 41% | … | |
| VEGF (pg/ml) | 225* (110–500) | 150* (118–235) | 83 (13–125) | <0.001 |
| sFlt-1 (ng/ml) | 17 (6–60) | 6* (2–19) | 28 (18–39) | 0.003 |
| von Willebrand factor (IU/dl) | 180 (53)* | 189 (80)* | 91 (19) | <0.001 |
Values are mean (SD), except for VEGF and sFlt-1, expressed as median (IQR)
NTG = normal tension glaucoma; POAG = primary open angle glaucoma; BP = blood pressure; VEGF = vascular endothelial growth factor; sFlt-1 = soluble VEGF receptor Flt-1.
*p<0.05 v controls, by Tukey’s post hoc test (after logarithmic transformation for VEGF and sFlt-1).