Table 1.
Patient characteristics
| Bimatoprost once daily (n=240) | Bimatoprost twice daily (n=240) | Timolol (n=122) | p Value | |
| Mean age (SEM) (years) | 60.3 (0.8) (range 22–83) | 61.4 (0.8) (range 33–90) | 60.0 (1.1) (range 33–83) | 0.459 |
| Sex | 0.623 | |||
| Male | 108 (45.0%) | 117 (48.8%) | 54 (44.3%) | |
| Female | 132 (55.0%) | 123 (51.3%) | 68 (55.7%) | |
| Race | 0.344 | |||
| White | 186 (77.5%) | 191 (79.6%) | 85 (69.7%) | |
| Black | 39 (16.3%) | 37 (15.4%) | 26 (21.3%) | |
| Asian | 0 (0.0%) | 1 (0.4%) | 2 (1.6%) | |
| Hispanic | 15 (6.3%) | 10 (4.2%) | 9 (7.4%) | |
| Other | 0 (0.0%) | 1 (0.4%) | 0 (0.0%) | |
| Iris colour | 0.125 | |||
| Blue | 69 (28.8%) | 55 (22.9%) | 24 (19.7%) | |
| Brown | 81 (33.8%) | 88 (36.7%) | 53 (43.4%) | |
| Green | 9 (3.8%) | 5 (2.1%) | 7 (5.7%) | |
| Dark brown | 22 (9.2%) | 21 (8.8%) | 13 (10.7%) | |
| Yellow-brown | 31 (12.9%) | 30 (12.5%) | 10 (8.2%) | |
| Grey | 1 (0.4%) | 4 (1.7%) | 0 (0.0%) | |
| Blue-grey | 6 (2.5%) | 10 (4.2%) | 3 (2.5%) | |
| Green-brown | 6 (2.5%) | 6 (2.5%) | 6 (4.9%) | |
| Blue/grey-brown | 11 (4.6%) | 16 (6.7%) | 2 (1.6%) | |
| Other | 4 (1.7%) | 5 (2.1%) | 4 (3.3%) | |
| Diagnosis | 0.407 | |||
| Glaucoma | 123 (51.3%) | 122 (50.8%) | 55 (45.1%) | |
| OHT* | 111 (46.3%) | 108 (45.0%) | 65 (53.3%) | |
| Glaucoma/OHT† | 6 (2.5%) | 10 (4.2%) | 2 (1.%) | |
| Washout required | 0.491 | |||
| Yes | 146 (60.8%) | 153 (63.8%) | 70 (57.4%) | |
| No | 94 (39.2%) | 87 (36.3%) | 52 (42.6%) | |
| Mean (SD) IOP at baseline (mm Hg) | ||||
| 8 am | 25.9 (3.2) | 26.1 (3.1) | 25.8 (2.9) | 0.529 |
| 10 am | 24.6 (3.9) | 24.8 (4.0) | 24.0 (3.6) | 0.232 |
| 4 pm | 23.9 (4.0) | 23.9 (4.2) | 23.2 (3.9) | 0.148 |
| 8 pm‡ | 21.4 (4.6) (n=39) | 22.6 (5.0) (n=39) | 22.6 (4.5) (n=20) | 0.608 |
*OHT=ocular hypertension.
†One eye with glaucoma and the fellow eye with ocular hypertension.
‡Measurements only at select sites (bimatoprost once daily, n=39; bimatoprost twice daily, n=39; timolol, n=20).