. 2003 Sep;87(9):1172–1174. doi: 10.1136/bjo.87.9.1172

Table 1.

Summary of estimated in vivo effective concentration of quinolones required with topical administration. Estimates of tissue concentrations obtained with oral and topical use in ideal conditions

	MIC₉₀ (mg/l)
	Ciprofloxacin	Gatifloxacin/moxifloxacin
S pneumoniae	2	0.12–0.5
S aureus (all)	0.25–2	0.06–0.13
MRSA	R	6.25/2.0
Ps aeruginosa	0.5(8)	3–32
Enterobacteriaceae	0.01–0.25	0.01–0.39
C_max (serum, mg/l)	2.4_{500 mg po}	4.2–4.5_{400/40 mg po}
Aqueous (mg/l)	0.69_{750 mg X3 po}
Cornea (mg/l)	0.6_{0.3% topical}