Table 1.

Odds ratios (OR) and 95% confidence intervals (CI) for associations between open angle glaucoma and reproductive factors

Characteristic	OR and 95% CI
	Glaucoma
	No at risk	%	Age adjusted	Multivariate adjusted*
Age at menarche (years)
<13	691	2.0	1.0	1.0
13	441	2.3	2.0 (1.1 to 3.7)	2.1 (1.1 to 3.8)
14+	824	5.0	1.9 (1.0 to 3.6)	2.0 (1.0 to 3.9)
			p for trend = 0.01	p for trend = 0.01
Age at menopause†(years)
All post-menopausal women
50+	788	3.3	1.0	1.0
45–49	442	3.9	1.3 (0.7 to 2.4)	1.2 (0.6 to 2.3)
<45	340	4.7	1.4 (0.7 to 2.8)	1.3 (0.7 to 2.6)
			p for trend = 0.26	p for trend = 0.40
Natural menopause‡
50+	719	3.1	1.0	1.0
45–49	346	3.8	1.3 (0.6–2.6)	1.2 (0.6–2.5)
<45	164	6.1	1.8 (0.8–4.0)	1.7 (0.7–3.8)
			p for trend = 0.14	p for trend = 0.24
Duration of endogenous oestrogen exposure†(years)
All post-menopausal women
40+	297	2.4	1.0	1.0
35–39	629	3.5	1.4 (0.6 to 3.4)	1.4 (0.6 to 3.3)
30–34	346	4.9	1.9 (0.8 to 4.7)	1.7 (0.7 to 4.3)
<30	287	4.5	1.8 (0.7 to 4.6)	1.6 (0.6 to 4.3)
			p for trend = 0.19	p for trend = 0.29
Natural menopause‡
40+	266	2.6	1.0	1.0
35–39	550	2.7	1.0 (0.4 to 2.5)	0.9 (0.4 to 2.4)
30–34	270	5.6	1.8 (0.7 to 4.7)	1.6 (0.6 to 4.2)
<30	133	6.0	1.8 (0.6 to 5.4)	1.8 (0.6 to 5.3)
			p for trend = 0.09	p for trend = 0.14

*Adjusted for age, history of diabetes, hypertension, myopia, pseudoexfoliation, and family history of glaucoma. †Excludes women with a hysterectomy only (n = 255). ‡Age at natural menopause missing in 47 women.