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Purine synthesis and degradation. MMF blocks the key enzyme IMPDH of the guanosine de novo synthesis. Guanosine is also produced by a salvage pathway from purine degradation. MMF = mycophenolate mofetil; IMPDH = inosine monophoshate dehydrogenase; HGPRT = hypoxanthine phosphoribosyl transferase, MP = monophoshate; DP = diphosphate (modified from Karlson11).
