Table 1.
Clinical data of blood pressure, heart rate, intraocular pressure, and calculated ocular perfusion pressure at baseline and after 2 weeks of treatment (mean (SD))
| Brinzolamide | Placebo | |||
| Baseline | Drug | Baseline | Placebo | |
| Systolic blood pressure (mm Hg) | 120 (17) | 118 (13) | 117 (9) | 120 (12) |
| Diastolic blood pressure (mm Hg) | 73 (11) | 71 (8) | 70 (7) | 72 (9) |
| Heart rate (beats/min) | 66 (9) | 69 (9) | 67 (11) | 66 (14) |
| Intraocular pressure (mm Hg) | 12.3 (2.0) | 9.4 (2.2)* | 13.2 (1.6) | 12.3 (2.2) |
| Ocular perfusion pressure (mm Hg) | 46.2 (8.2) | 47.8 (5.4) | 43.2 (5.0) | 45.7 (6.0) |
Apart from a significant decrease of intraocular pressure after brinzolamide no significant differences between visits were detected in both groups (ANOVA for repeated measures).
*p<0.0001 (Bonferroni-Dunn).