Table 2.

Ophthalmoscopic, electroretinographic, and histological findings with increasing doses of intravitreal tenecteplase

	Tenecteplase dose (μg)
	50 (n = 7)	150 (n = 5)	200 (n = 5)	250 (n = 7)
Ophthalmoscopy	Normal	Normal	TRD(2)	TRD(3)
			RA(1)	RN(2)
			Normal(2)	VF(2)
ERG B-wave amplitude	No reduction	Transitory reduction	Significant reduction	Significant reduction
Retinal histology	Normal	Mild damage	Significant damage	Significant damage

TRD  =  tractional retinal detachment; RA  =  retinal atrophy; RN  =  retinal necrosis; VF  =  vitreal fibrosis.