Table 3.
Intraocular pressure (IOP) and IOP reduction from baseline to month 6 (mm Hg): unadjusted mean (standard deviation) (intent to treat population)
| IOP | IOP reduction: baseline to month 6 | |||
| Fixed combination latanoprost/timolol (n = 163) | Unfixed combination brimonidine/timolol (n = 162) | Fixed combination latanoprost/timolol (n = 163) | Unfixed combination brimonidine/timolol (n = 162) | |
| Baseline | ||||
| 8:00AM | 27.4 (2.6) | 27.3 (2.4) | ||
| 12 noon | 26.3 (3.1) | 26.3 (3.2) | ||
| 4:00PM | 25.5 (3.4) | 25.8 (3.4) | ||
| Diurnal | 26.4 (2.7) | 26.5 (2.8) | ||
| Month 6 | ||||
| 8:00AM | 17.6 (3.1) | 19.1 (3.5) | 9.9 (3.6)* | 8.2 (3.2) |
| 2 noon | 16.8 (2.9) | 17.8 (3.2) | 9.5 (3.9)† | 8.4 (3.9) |
| 4:00PM | 16.3 (3.0) | 17.7 (3.2) | 9.2 (3.9)† | 8.1 (4.2) |
| Diurnal | 16.9 (2.8) | 18.2 (3.1) | 9.5 (3.4)* | 8.2 (3.4) |
*p<0.001, †p<0.02, t tests for differences between groups in mean IOP changes from baseline.