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Inferred growth of primary (solid line) and metastatic uveal melanoma (broken line) based on tumour doubling times. It takes 2.2 years after the diagnosis of primary tumour (point B) for the metastases to be clinically detected, point C. At the time of metastasis (point A), the primary tumour is estimated to be 7 mm3 and the metastases are subclinical. Reproduced with permission from Eskelin et al.43
