Table 6.

 Thickness variations of extraocular muscles relative to optic nerve size—efficacy population

Muscles	Treatment group* (n = 46)	Non-treatment group (n = 28)	Difference between groups
Inferior rectus:
Week 0			p = 0.0184
Mean (SD)	1.3 (0.7)	0.9 (0.3)
Range	(0.4–3.2)	(0.3–2.0)
Week 24, percentage change			p = 0.1173†
Mean (SD)	−13.2 (25.7)	−4.0 (21.5)
Range	(−60.6–69.1)	(−63.6–42.6)
Medial rectus:
Week 0			p = 0.0153
Mean (SD)	1.2 (0.6)	0.9 (0.3)
Range	(0.5–3.1)	(0.5–1.5)
Week 24, percentage change			p = 0.0900†
Mean (SD)	−8.2 (20.7)	0.6 (22.4)
Range	(−42.8–42.8)	(−27.8–66.7)
SRLP:
Week 0			p = 0.0506†
Mean (SD)	1.2 (0.6)	0.9 (0.3)
Range	(0.5–3.2)	(0.5–1.8)
Week 24, percentage change			p = 0.0060
Mean (SD)	−9.5 (29.1)	12.5 (37.5)
Range	(−63.8–78.6)	(−41.7–139.2)
Lateral rectus:
Week 0			p = 0.0662†
Mean (SD)	1.0 (0.4)	0.9 (0.4)
Range	(0.4–2.1)	(0.4–1.8)
Week 24, percentage change			p = 0.0765†
Mean (SD)	−11.5 (20.6)	−0.5 (31.6)
Range	(−63.1–39.2)	(−51.6–87.5)

n, number of eyes; *n = 45 for lateral rectus; †not significant.