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. 2004 Dec;88(12):1521–1526. doi: 10.1136/bjo.2004.047928

Table 2.

 Retinoblastomas enucleated and subjected to postoperative chemotherapy

Study No Age/sex Clinicopathological features P-gp LRP Chemotherapy Outcome
% Cells Intensity % Cells Intensity
41 3 years/M right eye: PD diffuse choroidal invasion and post-laminar optic nerve invasion. 70% + 20% +/− 7 cycles of triple chemotherapy No recurrence or metastasis
42 3 years/M left eye: PD, post-laminar optic nerve invasion 0 80% + 2 cycles of triple chemotherapy No recurrence or metastasis
43 10 months/M both eyes, right eye: WD, focal, choroidal, surgical end of optic nerve invasion 0 0 4 cycles of triple chemotherapy 6 months, child died (bone marrow metastasis)
44 3 years/F right eye, MD, post-laminar optic nerve invasion 0 0 6 cycles of triple chemotherapy No recurrence or metastasis
45 3 years/M left eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion 50% + 70% + 6 cycles of triple chemotherapy Orbital involvement. Exenteration done
46 4 years/F left eye: PD, post-laminar optic nerve invasion 0 0 4 cycles of triple chemotherapy No recurrence or metastasis
47 2½ years/M right eye: PD, diffuse choroidal invasion 0 0 3 cycles of triple chemotherapy Orbital recurrence
48 7 years/M left eye: PD, diffuse choroidal invasion, orbital invasion. post-laminar optic nerve invasion 0 0 Exenteration done, 6 cycles of chemotherapy Death with bone marrow metastasis
49 2 years/M both eyes, right eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion, orbital invasion 0 0 6 cycles of triple chemotherapy BM metastasis
50 5 years/F both eyes, left eye, WD, focal invasion of choroid post-laminar optic nerve invaded 60% + 0 2 cycles of triple for left eye No recurrence or metastasis
51 3 years/M left eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion 40% + 90% + left eye: 6 cycles of triple chemotherapy orbital recurrence
52 1 year 8 months/F left eye: PD diffuse choroidal invasion, post-laminar optic nerve invasion 0 0 5 cycles of triple chemotherapy orbital recurrence
53 2 years/M both eyes: right eye enucleated, PD; diffuse choroidal invasion 0 0 4 cycles of triple chemotherapy No recurrence or metastasis
54 2 years/M both eyes: right eye enucleated, PD; post-laminar optic nerve invasion 60% + 70% + 3 cycles of triple chemotherapy No recurrence or metastasis
55 2 years/M both eyes: right eye: enucleated, MD; post-laminar optic nerve invasion 0 0 right eye: triple chemotherapy No recurrence or metastasis
56 4 years/F left eye: PD; focal choroidal invasion, post-laminar optic nerve invasion 0 60% + left eye: 4 cycles of triple chemotherapy No recurrence or metastasis
57 13 months/F right eye: PD; focal choroidal invasion, post-laminar optic nerve invasion 0 30% + right eye: 6 cycles of triple chemotherapy No recurrence or metastasis
58 3 years/F right eye: PD; diffuse choroidal invasion; post-laminar optic nerve invasion 20% + 30% + right eye: 7 cycles of triple chemotherapy No recurrence or metastasis
59 2 years/F left eye: PD; diffuse choroidal; surgical end of optic nerve involved 0 0 left eye: 4 cycles of triple chemotherapy No recurrence or metastasis
60 4 years/M left eye: PD; diffuse choroidal invasion; post-laminar optic nerve invasion. 20% +/− 40% + left eye: 6 cycles of triple chemotherapy No recurrence or metastasis.

PD, poorly differentiated; MD, moderately differentiated; WD, well differentiated.

HHS Vulnerability Disclosure