Table 2.
Retinoblastomas enucleated and subjected to postoperative chemotherapy
Study No | Age/sex | Clinicopathological features | P-gp | LRP | Chemotherapy | Outcome | ||
% Cells | Intensity | % Cells | Intensity | |||||
41 | 3 years/M | right eye: PD diffuse choroidal invasion and post-laminar optic nerve invasion. | 70% | + | 20% | +/− | 7 cycles of triple chemotherapy | No recurrence or metastasis |
42 | 3 years/M | left eye: PD, post-laminar optic nerve invasion | 0 | − | 80% | + | 2 cycles of triple chemotherapy | No recurrence or metastasis |
43 | 10 months/M | both eyes, right eye: WD, focal, choroidal, surgical end of optic nerve invasion | 0 | − | 0 | − | 4 cycles of triple chemotherapy | 6 months, child died (bone marrow metastasis) |
44 | 3 years/F | right eye, MD, post-laminar optic nerve invasion | 0 | − | 0 | − | 6 cycles of triple chemotherapy | No recurrence or metastasis |
45 | 3 years/M | left eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion | 50% | + | 70% | + | 6 cycles of triple chemotherapy | Orbital involvement. Exenteration done |
46 | 4 years/F | left eye: PD, post-laminar optic nerve invasion | 0 | − | 0 | − | 4 cycles of triple chemotherapy | No recurrence or metastasis |
47 | 2½ years/M | right eye: PD, diffuse choroidal invasion | 0 | − | 0 | − | 3 cycles of triple chemotherapy | Orbital recurrence |
48 | 7 years/M | left eye: PD, diffuse choroidal invasion, orbital invasion. post-laminar optic nerve invasion | 0 | − | 0 | − | Exenteration done, 6 cycles of chemotherapy | Death with bone marrow metastasis |
49 | 2 years/M | both eyes, right eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion, orbital invasion | 0 | − | 0 | − | 6 cycles of triple chemotherapy | BM metastasis |
50 | 5 years/F | both eyes, left eye, WD, focal invasion of choroid post-laminar optic nerve invaded | 60% | + | 0 | − | 2 cycles of triple for left eye | No recurrence or metastasis |
51 | 3 years/M | left eye: PD, diffuse choroidal invasion, post-laminar optic nerve invasion | 40% | + | 90% | + | left eye: 6 cycles of triple chemotherapy | orbital recurrence |
52 | 1 year 8 months/F | left eye: PD diffuse choroidal invasion, post-laminar optic nerve invasion | 0 | − | 0 | − | 5 cycles of triple chemotherapy | orbital recurrence |
53 | 2 years/M | both eyes: right eye enucleated, PD; diffuse choroidal invasion | 0 | − | 0 | − | 4 cycles of triple chemotherapy | No recurrence or metastasis |
54 | 2 years/M | both eyes: right eye enucleated, PD; post-laminar optic nerve invasion | 60% | + | 70% | + | 3 cycles of triple chemotherapy | No recurrence or metastasis |
55 | 2 years/M | both eyes: right eye: enucleated, MD; post-laminar optic nerve invasion | 0 | − | 0 | − | right eye: triple chemotherapy | No recurrence or metastasis |
56 | 4 years/F | left eye: PD; focal choroidal invasion, post-laminar optic nerve invasion | 0 | − | 60% | + | left eye: 4 cycles of triple chemotherapy | No recurrence or metastasis |
57 | 13 months/F | right eye: PD; focal choroidal invasion, post-laminar optic nerve invasion | 0 | − | 30% | + | right eye: 6 cycles of triple chemotherapy | No recurrence or metastasis |
58 | 3 years/F | right eye: PD; diffuse choroidal invasion; post-laminar optic nerve invasion | 20% | + | 30% | + | right eye: 7 cycles of triple chemotherapy | No recurrence or metastasis |
59 | 2 years/F | left eye: PD; diffuse choroidal; surgical end of optic nerve involved | 0 | − | 0 | − | left eye: 4 cycles of triple chemotherapy | No recurrence or metastasis |
60 | 4 years/M | left eye: PD; diffuse choroidal invasion; post-laminar optic nerve invasion. | 20% | +/− | 40% | + | left eye: 6 cycles of triple chemotherapy | No recurrence or metastasis. |
PD, poorly differentiated; MD, moderately differentiated; WD, well differentiated.