Table 2.
The median minimum inhibitory concentrations (MIC90) of common pathogens to moxifloxacin
| Isolated in bacterial endophthalmitis cases (peak aqueous levels/MIC90) (μg/ml) | Isolated in systemic infections (peak aqueous levels/MIC90) (μg/ml) | |
| MSSA | 0.12 (13.3) | |
| MRSA | 4 | |
| Staphylococcus aureus FQR | 1.75 | |
| Staphylococcus aureus FQS | 0.06 (26.6) | 0.06 |
| CoagNeg staphylococcus FQR | 2.5 | 2 |
| CoagNeg staphylococcus FQS | 0.05 (32) | 0.13 (12.3) |
| Streptococcus pneumoniae | 0.09 (17.7) | 0.25 |
| Streptococcus viridans | 0.13 (12.3) | 0.25 |
| Enterococcus species | 0.19 (8.4) | 0.5 |
| Gram negatives | 0.08 (20) | 0.25 (6.4) |
| Bacillus species | 0.09 (17.7) | |
| Escherichia coli | 0.06 (26.6) | |
| Neisseria species | 0.015 (106) | |
| H influenzae | 0.06 (26.6) | |
| Pseudomonas aeruginosa | 8 |
FQR, resistant to ciprofloxacin and ofloxacin as determined by disc diffusion; FQS, susceptible to ciprofloxacin and ofloxacin as determined by disc diffusion; Gram negatives, assortment of various Gram negative bacteria isolated from endophthalmitis cases (mainly Haemophilus sp and P aeruginosa)13; MSSA, methicillin sensitive Staphylococcus aureus; MRSA, methicillin resistant Staphylococcus aureus.