Table 3.

 Correlations among plasma angiogenic growth factors, their receptors, and von Willebrand factor in 23 AA subjects and 56 SCD patients

	vWf	VEGF	sFlt-1	Ang-1	Ang-2	Tie-2
23 AA subjects
VEGF	−0.026, 0.908	–	–	–	–	–
sFlt-1	0.099, 0.624	0.627, 0.001*	–	–	–	–
Ang-1	0.269, 0.215	0.505, 0.014*	0.483, 0.020*	–	–	–
Ang-2	0.209, 0.338	0.369, 0.083	0.244, 0.263	0.245, 0.260	–	–
Tie-2	−0.074, 0.739	0.546, 0.007*	0.526, 0.010*	0.501, 0.015*	–	–
56 SCD patients
VEGF	0.120, 0.380	–	–	–	–	–
sFlt-1	0.114, 0.401	0.882, <0.001*	–	–	–	–
Ang-1	0.279, 0.037*	0.677, <0.001*	0.610, <0.001*	–	–	–
Ang-2	0.165, 0.225	0.645, <0.001*	0.699, <0.001*	0.591, <0.001*	–	–
Tie-2	0.317, 0.017	0.743, <0.001*	0.766, <0.001*	0.743, <0.001*	0.516, <0.001*	–

Data presented as Spearman correlation coefficient (r) followed by p values. *p Values <0.05.

Ang-1: angiopoietin-1, Ang-2: angiopoietin-2, Tie-2: the angiopoietin receptor Tie-2, VEGF, vascular endothelial growth factor, sFlt-1, the VEGF receptor Flt-1; vWf, von Willebrand factor.