Table 3.
50 Most abundant genes expressed by native macular RPE cells
| Gene name | GenBank Acc No | Signal (AU)* | Biological function |
| Cut-like 1, CCAAT displacement protein (Drosophila) | AA284408 | 49.2 | Development |
| cDNA FLJ34046 fis, clone FCBBF2007610 | W15465 | 44.7 | Unknown |
| Solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 | N49856 | 37.7 | Neurotransmitter |
| Nephronophthisis 3 (adolescent) | H93118 | 36.3 | Unknown |
| Junctional adhesion molecule 2 | R68464 | 36.2 | Cell adhesion |
| Prefoldin 4 | AA253430 | 35.9 | Protein folding |
| EST | R32754 | 34.1 | Unknown |
| Selenoprotein T | R78516 | 33.5 | Antioxidant |
| Ubiquitin conjugating enzyme E2I (UBC9 homologue, yeast) | AA487197 | 33.1 | Protein degradation |
| Biogenesis of lysosome related organelles complex-1, subunit 1 | H94857 | 32.2 | Unknown |
| CDC28 protein kinase regulatory subunit 1B | AA459292 | 31.4 | Cell cycle |
| d-dopachrome tautomerase mRNA, complete cds | AA292995 | 31.0 | Unknown |
| Zinc finger protein 258 | AA280676 | 29.4 | Development |
| Endothelin converting enzyme 1 | AA279429 | 28.6 | Cell-cell signalling |
| Multiple endocrine neoplasia I | AA261796 | 27.6 | Transcription regulation |
| CDC28 protein kinase regulatory subunit 2 | AA397813 | 27.0 | Cell cycle |
| Interleukin 24 | AA281635 | 26.5 | Immune response, apoptosis |
| EST | N92646 | 26.0 | Unknown |
| Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 | AA448184 | 24.9 | electron transport |
| Profilin 1 | AA521431 | 23.5 | Cell structure |
| BCL2 related protein A1 | AA459263 | 23.1 | Apoptosis inhibition |
| EST | R76499 | 23.1 | Unknown |
| Kinesin family member 5B | AA046690 | 21.9 | Organelle transport |
| Rho GTPase activating protein 1† | AA443506 | 21.5 | Cell structure |
| Adaptor related protein complex 1, γ1 subunit | W07300 | 21.5 | Protein sorting |
| NudE nuclear distribution gene E homologue-like 1 (A. nidulans) | R94775 | 21.1 | Unknown |
| EST | H93842 | 20.8 | Unknown |
| Sarcolipin | AA196465 | 20.7 | Intracellular transport |
| Myeloid cell nuclear differentiation antigen | N29376 | 20.7 | Transcription regulation |
| PDGFA associated protein 1† | AA490300 | 20.6 | Cell cycle |
| Guanine nucleotide binding protein (G protein), α inhibiting activity polypeptide 3 | AA490256 | 20.3 | Unknown |
| Chitinase 3-like 1 (cartilage glycoprotein-39) | AA434115 | 20.2 | Metabolism |
| EST | H93906 | 20.1 | Unknown |
| Chromosome 14 open reading frame 2 | T90621 | 20.1 | Unknown |
| Ataxin 2 related protein | AA029963 | 19.9 | Unknown |
| Zinc finger protein 258 | AA280677 | 19.9 | Development |
| DnaJ (Hsp40) homolog, subfamily B, member 1 | AA481758 | 19.8 | Protein folding |
| Vesicle docking protein p115 | AA504342 | 19.5 | Vesicle docking during exocytosis |
| Secretory carrier membrane protein 2 | R32802 | 19.4 | Protein transport |
| Cas-Br-M (murine) ecotropic retroviral transforming sequence | N94234 | 19.4 | Cell growth |
| EST | T60223 | 19.3 | Unknown |
| Chromosome X open reading frame 12 | AA455272 | 18.8 | Unknown |
| EST | R69566 | 18.8 | Unknown |
| Decay accelerating factor for complement (CD55, Cromer blood group system) | R09561 | 18.6 | Complement pathway |
| CTF8, chromosome transmission fidelity factor 8 homologue (S cerevisiae) | N57731 | 18.5 | Unknown |
| EST | R25153 | 18.5 | Unknown |
| Villin 2 (ezrin) | AA411440 | 18.5 | Cell structure |
| Ankyrin repeat domain 1 (cardiac muscle) | AA488072 | 18.5 | Defence response |
| Cytoskeleton associated protein 1 | AA504554 | 18.5 | Cell structure |
| EST | W44701 | 18.3 | Unknown |
*AU, arbitrary units.
†Indicate genes not in the top 50 of cultured RPE cells (any condition).