Fig. 1.

Loss of MHC class I is limited to the APC compartment in class I APC-bald NOD mice. Class I APC-bald NOD mice (n = 6), class I APC-normal NOD mice (n = 5), and NODβ₂M^−/− (n = 6) were analyzed for H-2K^d expression by FACS. Total conventional DCs (CD11c⁺), B lymphocytes (B220⁺ or CD19⁺), and macrophages (I-A^g7+ F4/80⁺ CD11b⁺) are shown, and the mean percentages (±SD) of H-2K^d-sufficient cells are indicated. All APC cell types from class I APC-bald NOD mice were largely deficient in MHC class I. In contrast, as expected, splenic T lymphocytes (CD4⁺, TCR⁺; Far Right) remain MHC class I-sufficient.