Fig. 2.

APCs of class I APC-bald NOD mice are unable to activate CD8 T cells in vivo. CFSE-labeled 8.3 TCR transgenic CD8 T cells were injected into either class I APC-normal mice (n = 5) or class I APC-bald NOD mice (n = 6). Six days after transfer, the percentage of proliferating 8.3 TCR⁺ CD8 T cells (R1) in the pancreatic lymph nodes of class I APC-normal mice (Upper) and class I APC-bald mice (Lower) was determined by flow cytometry. This result was representative of two independent experiments.