Table 1.

Histopathological results in 16 beagles

Dog	0 month	3 months	6 months	8 months	10 months	12 months	14 months	15 months
T1	N	F		D				D
T2	N			Pa, D++	D++	S		S, P, Pa, O
T3	N	D+∼++					S	P, S, Pa, T, D
T4	N			D+		D+	D++	F, D++
T5	N				F			Pa, D++
T6	N				D+	S, D++		S
T7	N				D+	D+		D+
T8	N					D+	D+	D+
C9	N		D			T	T	S, P, T, Pa
C10	N				S, D++	D+	Pa	S, P, T, Pa
C11	N				S	S	Pa	S, Pa, T
C12	N			D+		S	F	P, S, T
C13	N			D+∼++		S	F	P, S, T
C14	N					S	Pa	S
C15	N					D++	P, S	P, S, D+
C16	N		D+				D++	S

N, normal; D, dysplasia (+mild, ++moderate, +++severe); F, fibrotic proliferation; S, signet ring cell carcinoma; Pa, papillary adenoma; P, poorly differentiated adenocarcinoma; O, oesophageal carcinoma; T, tubular adenocarcinoma.

T1–8, folic acid treated beagles; C9–16, control beagles.