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Immunohistochemical localisation of the somatostatin receptor (sstr) subtypes in an insulinoma showing that sstr1 (A), sstr3 (C), and sstr5 (D) are detected in single cells which are surrounded by non-immunostained tumour cells. In contrast, sstr2A (B) is present in nearly all tumour cells. (Scale bar A–D=30 μm.)
