Table 1.
Serum levels of nitrite/nitrate (μmol/l) in patients with chronic active Crohn's disease treated with either placebo (n=10), or recombinant human interleukin 10 at 1 (n=12), 4 (n=12), 8 (n=10), or 20 (n=10) μg/kg body weight subcutaneously over 28 days
| Group | Day −1 | Day +15 | Day +29 | p Value* | Follow up week 4 |
| Placebo | 31.6 (3.6) | 32.4 ( 4.0) | 30.4 (3.2) | 0.79 | 36.4 (4.8) |
| 1 μg/kg | 29.6 (4.0) | 38.4 (10.6) | 22.8 (3.2) | 0.27 | 28.0 (3.6) |
| 4 μg/kg | 46.0 (9.6) | 46.8 (10.4) | 43.6 (10.8) | 0.79 | 38.0 (8.0) |
| 8 μg/kg | 38.0 (6.4) | 38.8 (5.2) | 47.6 (8.8) | 0.5 | 40.0 (5.2) |
| 20 μg/kg | 34.4 (6.0) | 39.6 (8.0) | 46.0 (11.6) | 0.29 | 32.8 (6.8) |
Data are mean (SEM).
*Statistical analysis was performed using ANOVA.