Figure 4.

Effects of infliximab on Jurkat T cells. (A) Bax/Bcl2 ratio in Jurkat cells determined by FACScan analysis. Data are expressed as mean (SEM) of six independent experiments. Jurkat cells were incubated for 24 hours with IgG isotype control, infliximab (Inflix), RPMI, and anti-Fas antibody. Cells were either not stimulated (left) or stimulated with anti-CD3/anti-CD28 antibodies (right). (B) Quantitative results of a TUNEL assay on cytospins of Jurkat cells. TUNEL positive cells were counted in non-stimulated (left) and stimulated (right) cells.