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. 2002 Mar;50(3):355–360. doi: 10.1136/gut.50.3.355

Figure 1.

Figure 1

(A) Dissection of the entire gastrointestinal tract. The severe intestinal enlargement is shown in the homozygous endothelin ETB receptor null rat (ETB(−/−)R) compared with the homozygous wild type ETB(+/+)R. Dilation of the proximal ileum was observed in the intestine of the homozygous ETB(−/−)R. (B) Whole mount preparations of the colon and proximal ileum from the ETB(+/+)R and ETB(−/−)R stained with anti-PGP9.5 antibody. The ETB(+/+)R shows a close regular pattern of the plexus (arrowheads) whereas in the ETB(−/−)R only a nerve bundle (arrowhead) is observed (colon), and the myenteric plexus (arrowhead) appears to have a decreased number of ganglia and to be somewhat stretched (ileum). Bar=100 μm.