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Contractile effects of endothelin-1 on the proximal (A) and distal (B) parts of the ileum in the homozygous endothelin ETB receptor null rat (ETB(−/−)R) compared with the homozygous wild type ETB(+/+)R. Contractile responses are expressed in mN per mg tissue wet weight (mN/mg ww). Each point represents the mean (SEM) of nine or 10 experiments. Significantly different from the ETB(+/+)R: *p<0.05, **p<0.01.
