Figure 3.

Minichromosome maintenance protein 2 (Mcm2) expression in Barrett's mucosa. On the right of (A), non-dysplastic intestinal type “specialised” Barrett's mucosa shows Mcm2 expression in cells of the proliferative zone beneath the mucosal surface. Expression falls away markedly on the mucosal surface. There is an abrupt transition (arrow) to mucosa showing mild (low grade) dysplasia in which Mcm2 downregulation does not occur. More pronounced but still low grade Barrett's dysplasia (B) shows strong Mcm2 expression in the upper crypt and surface, with weaker expression in deep glands.