Figure 8.

Changes in short circuit current (I_sc) across mouse distal colon over a three hour period of measurements for two typical experiments of control (A) and tumour necrosis factor α (TNF-α) exposed tissues (B). At t=0 tissues were mounted and transepithelial potential and transepithelial resistance were continuously recorded. Every 30 minutes Ringer's solution was replaced which shows as a drop in I_sc during the recording. Histamine was added at the time point indicated by the arrow. The frames are enlarged in the inset. Two typical recordings of I_sc from mouse distal colon of control and TNF-α exposed tissues are presented in the inset. The change in current with respect to baseline levels is indicated by ΔI_sc. The recordings represent four experiments for each group. The corresponding electrophysiological data are presented in table 2 ▶. Statistical significance was evaluated using the Student's t test.