Table 3.
Colon cancer (n=8) | CD non-inflamed (n=5) | CD inflamed (n=4) | ||||
Time | ATP | ECP | ATP | ECP | ATP | ECP |
0 min | 6.3 (5.2–6.7) | 0.71 (0.68–0.76) | 6.0 (5.3–7.1) | 0.73 (0.71–0.76) | 6.1 (4.9–6.5) | 0.72 (0.69–0.74) |
15 min vehicle | 6.0 (4.6–6.3) | 0.70 (0.68–0.74) | 5.6 (5.1–6.1) | 0.74 (0.70–0.77) | 3.6† (3.0–4.3) | 0.64† (0.62–0.67) |
15 min C10 | 2.1* (1.7–2.6) | 0.53* (0.51–0.57) | 2.4* (2.2–2.7) | 0.56* (0.50–0.59) | 2.3* (1.8–2.4) | 0.54* (0.47–0.56) |
Data are given as median (25–75th percentiles) at the start of the experiment—that is, after 40 minutes of equilibration in Ussing chambers (0 minutes), and after 15 minutes exposure to vehicle or sodium caprate (C10).
ATP concentrations are given as μg/mg dry weight.
*Decreased ATP concentrations compared with vehicle experiments (p<0.05); †decrease compared with baseline values in the same group and compared with vehicle experiments in the two non-inflamed groups (p<0.05).