Table 3.

Histological findings at presentation, HLA data, and outcome following standard steroid therapy in the 12 patients

	Liver histology			HLA
Patient No	Grade	Stage	Biliary changes	A	B	DR	Outcome	IAIHG score
1	3	0	No	na	na	na	Complete response + relapse	20
2	4	3	No	na	na	na	No response. Still requires multiple therapy after 3 y.	19
3	3	4	Yes	1, 10	7, 17	4, 13	Partial response. Complete response after 2 y.	18
4	4	0	No	3, 28	18, 35	4, 11	Complete response + relapse. OLT after 4 y. Died 3 y post-OLT.	21
5	4	0	No	na	na	na	No response. Still requires multiple therapy after 5 y.	19
6	3	4	No	1, 24	8, 39	4, 4	Complete response. No relapse. Recent OLT (after 14 y).	21
7	4	0	No	na	na	na	Partial response. Still requires multiple therapy after 10 y.	19
8	3	3	Yes	1, 2	35, 35	7, 13	Complete response + relapse	25
9	2	4	Yes	na	na	na	Partial response. Still requires multiple therapy after 4 y.	21
10	4	0	No	1, 32	51, 51	3, 7	No response. Emergency OLT. Died 10 days post-OLT .	16
11	0	4	No	na	na	na	No response. Listed for OLT 3 y later but died pre-OLT.	14
12	1	4	No	1, 2	5, 7	4, 11	No response. OLT after 3 mo. Still alive 7 y post-OLT.	16

Histological grading and staging according to Batts and Ludwig,¹⁹ as described in patients and methods.

Biliary changes include one or more of the following: pericholangitis, apparent ductopenia, ductular proliferation, copper associated protein deposition, cholestasis.

na, data not available; OLT, orthotopic liver transplant; IAIHG score, International Autoimmune Hepatitis Group score (including scoring for initial response to therapy).¹,²⁰