Table 5.
Odds ratios (OR) for coeliac disease concordance among non-index twins, estimated by logistic regression
Characteristic | Concordant pairs for CD | Adjusted OR (95% CI) |
Zygosity and No of shared haplotypes | ||
DZ sharing 0 or 1 haplotype | 2/21 (10%) | 1.0 |
DZ sharing 2 haplotypes | 1/6 (17%) | 1.4 (0.0–27.4) |
MZ | 15/20 (75%) | 17.0 (2.1–134.0) |
DQ genotype | ||
Not DQ2 or DQ8 | 2/12 (17%) | 1.0 |
DQ2 | 15/29 (52%) | 3.3 (0.4–30.0) |
DQ8 | 1/6 (17%) | 1.4 (0.0–41.0) |
Sex of the non-index twin | ||
Male | 6/22 (27%) | 1.0 |
Female | 12/25 (48%) | 1.3 (0.2–8.5) |
Age at enrolment (y) | ||
≤10 | 5/17 (29%) | 1.0 |
11–30 | 9/22 (41%) | 1.6 (0.2–11.0) |
>30 | 4/8 (50%) | 2.2 (0.2–27.7) |
MZ, monozygotic, DZ, dizygotic.
95% CI, 95% confidence interval.