Table 3.

Odds ratios of cancer of the colorectum, colon, or rectum for quartiles of serum IGF-1 and IGFBP-3, mutually adjusted

	Quartile
	1	2	3	4	p for trend
IGF-1 adjusted for IGFBP-3
Colorectum
OR	1.00	1.18	1.18	1.27	0.56
95% CI		0.65–2.14	0.60–2.29	0.62–2.63
Colon
OR	1.00	1.81	2.16	2.47	0.08
95% CI		0.83–3.98	0.91–5.14	0.93–6.53
Rectum
OR	1.00	0.50	0.38	0.43	0.23
95% CI		0.15–1.69	0.10–1.41	0.11–1.59
IGFBP-3 adjusted for IGF-1
Colorectum
OR	1.00	0.82	1.31	1.32	0.20
95% CI		0.44–1.54	0.68–2.54	0.66–2.67
Colon
OR	1.00	0.86	1.70	1.75	0.07
95% CI		0.39–1.91	0.73–3.94	0.72–4.22
Rectum
OR	1.00	0.79	0.81	0.58	0.45
95% CI		0.27–2.30	0.25–2.66	0.16–2.16

Conditional logistic regression analyses were matched for age, sex, date of blood sampling, fasting status, and time of last food consumption and further adjusted for smoking status.

IGF-I, insulin-like growth factor 1; IGFBP, IGF binding protein; OR, odds ratio; CI, confidence interval.