Figure 1.

(A) Electrical responses of ischaemic injured porcine ileal mucosa to treatment with cyclooxygenase (COX) inhibitors. Forty five minutes of ischaemia resulted in baseline transepithelial resistance (R) ∼50% that of control. Untreated ischaemic injured tissues recovered control levels of R within 180 minutes whereas tissues treated with the non-selective COX inhibitor indomethacin (5×10⁻⁶ M) did not fully recover. However, ischaemic injured tissues treated with the selective COX-2 inhibitor NS-398 (5×10⁻⁶ M) or selective COX-1 inhibitor SC-560 (5×10⁻⁶ M) recovered levels of R not significantly different from control within three hours. *p<0.05 versus control. Significance was determined by one way ANOVA, n=12. (B) Mucosal to serosal fluxes (J_ms) of mannitol across control and ischaemic injured tissues during a 240 minute recovery period. J_ms mannitol in ischaemic injured tissues was significantly greater than control during the first flux period (60–120 minutes) regardless of treatment. While J_ms mannitol recovered to levels not significantly different from control by 240 minutes in untreated ischaemic injured tissues or those treated with NS-398 (5×10⁻⁶ M) or SC-560 (5×10⁻⁶ M), J_ms mannitol in indomethacin treated tissues remained greater than control levels throughout the recovery period. *p<0.05 versus control tissues. Significance was determined using one way ANOVA, n=8.