Figure 2.

Histological appearance of ischaemic injured porcine ileal mucosa. (A) Ischaemia for 45 minutes resulted in lifting and sloughing of epithelium from the tips of villi. (B) After a 240 minute in vitro recovery period, villi contracted and epithelial restitution was complete. (C) Treatment of tissues with indomethacin (5×10⁻⁶ M) had no observable effect on restitution in tissues recovered in vitro for 240 minutes. (D) Similarly, tissues treated with NS-398 (5×10⁻⁶ M) had evidence of villous contraction and complete epithelial restitution. 1 cm bar=100 μm.