Table 1.

Pathohistological data and INK4a-ARF alterations

			p14 alterations			p16 alterations
Patient No	Sex (M/F)	Tumour size diameter (cm)	RE-PCR	MSP	EXP	RE-PCR	MSP	EXP	Allelic status
1	F	2.5	—	—	+++	+++	+++	—	ND
2	F	4.9	—	—	+++	—	—	+++	ND
3	F	10.5	—	—	+++	—	—	+++	ND
4	M	5.5	—	—	+++	—	—	+++	ND
5	F	6.5	—	—	+++	—	—	+++	ND
6	F	3.0	—	—	+++	—	—	+++	ND
7	F	12.5	—	—	+++	—	—	+++	ND
8	F	7.6	—	—	+++	—	—	+++	ND
9	M	8.0	—	—	+++	—	—	+++	NI
10	F	8.5	—	—	+++	—	—	+++	ND
11	F	10.8	+++	+++	—	—	—	+++	ND
12	F	4.5	—	—	+++	—	—	+++	ND
13	F	14.0	—	—	+++	—	—	+++	NI
14	F	10.5	—	—	+++	—	—	+++	ND
15	F	9.5	—	—	+++	—	—	+++	ND
16	F	8.2	+++	+++	—	—	—	+++	ND
17	F	7.5	—	—	+++	—	—	+++	ND
18	F	9.6	—	—	+++	+++	+++	—	ND
19	M	8.3	—	—	+++	—	—	+++	ND
20	F	7.8	—	—	+++	—	—	+++	ND
21	F	3.9	—	—	+++	+++	+++	—	ND
22	F	9.0	—	—	+++	+++	+++	—	ND
23	F	6.5	—	—	+++	+++	+++	—	ND
24	F	10.2	+++	+++	—	—	—	+++	ND
25	F	7.8	—	—	+++	+++	+++	—	ND

RE-PCR, restriction enzyme related-polymerase chain reaction; MSP, methylation specific PCR; EXP, gene mRNA expression analysed by reverse transcription PCR; ND, not detected (wild-type, both allels expressed as defined by multiplex PCR); NI, not informative.