Table 2.

Accuracy for diagnosis and prediction of development of pancreatic necrosis in acute pancreatitis. Receiver operating curve (ROC) analysis in patients with acute pancreatitis (n=85) and acute abdominal pain of non-pancreatic origin (n=53)

	Diagnosis				Necrosis
Analysis time (h)*	Cut off (nmol/l)	Sens (%)	Spec (%)	Accuracy (AUC*)	Cut off (nmol/l)	Sens (%)	Spec (%)	Accuracy (AUC*)
ProCAPB <48 h	2.5	95	95	0.990	13.2	71	49	0.565
ProCAPB 48–72 h	1.2	94	94	0.982	6.5	88	44	0.663
ProCAPB 72–96 h	2.5	99	82	0.968	27.4	97	11	0.511
CAPAP <48 h	0.3	81	83	0.850	3.2	95	87	0.920
CAPAP 48–72 h	0.5	40	90	0.675	0.4	89	84	0.882
CAPAP 72–96 h	0.3	33	84	0.527	0.3	67	89	0.848
Amylase†/CRP‡ <48 h	304† U/l	90	87	0.902	28‡ mg/l	60	68	0.635
Amylase† /CRP‡ 48–72 h	262† U/l	92	87	0.912	129‡ mg/l	93	66	0.845
Amylase† /CRP‡ 72–96 h	201† U/l	82	77	0.819	148‡ mg/l	100	65	0.878

AUC, area under the curve in the ROC plot; CAPAP, carboxypeptidase B activation peptide; proCAPB, procarboxypeptidase B.

*Time after onset of symptoms to blood sampling (hours).

†Amylase for diagnosis; ‡CRP for prediction of necrosis.