Table 4.
Gastric clarithromycin transfer: effect of acid secretion, Helicobacter pylori, iodoacetamide, and pronase
| Intravenous drug | Omeprazole | Pentagastrin | Omeprazole | Omeprazole | Omeprazole |
| Gastric luminal solution | 0.9% saline | 0.9% saline | 0.9% saline | 0.9% saline | Pronase |
| Preparation | Normal | Normal | H pylori infected | Iodoacetamide | Normal |
| n | 8 | 8 | 8 | 7 | 7 |
| Median gastric aspirate pH (range) | 6.13 (5.89–6.35) | 2.58 (2.30–2.85)**** | 6.19 (6.15–6.46) | 5.83 (5.58–6.34) | 6.60 (6.56–6.72)**** |
| Gastric aspirate Cmax (mg/l) | 8.7 (1.8) | 4.4 (4.5)* | 10.3 (1.6) | 6.7 (2.2) | 7.3 (2.4) |
| Gastric clearance (l/min) | 128 (31) | 30 (33)*** | 158 (22)* | 95 (29)** | 82 (18)*** |
| Gastric transfer fraction (%) | 2.28 (0.25) | 0.55 (0.63)**** | 2.09 (0.22) | 1.72 (0.41)*** | 1.33 (0.35)**** |
Values are mean (SD), except for pH.
*p<0.05, **p=0.06 , ***p<0.01, ****p<0.001 versus control.