Table 2.

Renal function evaluated during four hours of standing and during maintenance of the supine position

	Supine	Standing
Plasma AR concentration (μU/ml)
Controls	22.3 (11.5)	41.5 (36.2)**
Cirrhosis	18.1 (5.9)	36.7 (37.2)**
Plasma A concentration (pg/ml)
Controls	105.0 (55.0)	167.8 (40.8)**
Cirrhosis	77.9 (63.9)	200.8 (81.2)**
GFR (ml/min)
Controls	112.5 (15.9)	119.2 (37)
Cirrhosis	147 (22.8)††	145.6 (36.5)††
UNaV (μEq/min)
Controls	159 (105)	148 (128)
Cirrhosis	146 (81)	135 (78)
FlNa (mEq/min)
Controls	15.8 (2.1)	16.8 (5.1)
Cirrhosis	19.9 (6.0)††	19.8 (12.4)††
FENa (%)
Controls	1.09 (0.87)	0.88 (0.20)
Cirrhosis	0.73 (0.48)	0.68 (0.10)†
CLi (ml/min)
Controls	26.9 (21.0)	20.4 (14.2)
Cirrhosis	30.5 (10.2)	21.6 (8.6)*
PFR (ml/min)
Controls	85.1 (50.3)	101.3 (59.6)
Cirrhosis	116.49 (42.2)	123.9 (39.5)
PTRNa (mEq/min)
Controls	11.90 (1.9)	13.97 (3.0)
Cirrhosis	15.70 (4.1)††	16.85 (6.5)††
FELi (%)
Controls	24.4 (8.2)	17.6 (9.0)
Cirrhosis	20.8 (4.9)	12.8 (4.4)**††
DDNa (mEq/min)
Controls	3.88 (2.50)	2.87 (2.10)
Cirrhosis	4.22 (1.48)	2.94 (0.90)
DRNa (mEq/min)
Controls	3.42 (1.5)	2.72 (0.3)
Cirrhosis	4.10 (1.3)	2.81 (2.9)
DFRNa (%)
Controls	95.6 (4.0)	94.6 (1.1)
Cirrhosis	97.1 (1.2)	95.5 (1.0)

Data are mean (SD)

*p<0.03, **p<0.01 compared with values measured while supine (Wilcoxon signed rank test); †p<0.03, ††p<0.05 compared with controls (Wilcoxon rank sum test).

A, aldosterone; AR, active renin; CLi, lithium clearance; DDNa, distal sodium delivery; DRNa, distal sodium reabsorption; DFRNa, distal fractional sodium reabsorption; FELi, fractional lithium excretion; FENa, fractional sodium excretion; FlNa, filtered sodium load; GFR, glomerular filtration rate; PFR, proximal tubular reabsorption of fluid; PTRNa, proximal tubular reabsorption of sodium; UNaV, urinary sodium excretion.