Table 2.

Associations between methylation and molecular features of colorectal cancer

	Methylation (%)
Feature (n)	p16	MDR1	MINT-2	One	Two	Three
Total (275)	100 (36)	67 (24)	102 (37)	141 (51)	88 (32)	40 (15)
TP53
Wild-type (152)	59 (39)	40 (26)	62 (41)	79 (52)	54 (36)	28 (18)
Mutant (103)	30 (29)*	18 (18)†	26 (25)‡	46 (44)	21 (20)‡	7 (7)‡
K-ras
Wild-type (138)	51 (37)	41 (30)	50 (36)	67 (46)	49 (36)	26 (19)
Mutant (65)	17 (26)*	7 (11)§	18 (28)	28 (44)	11 (17)‡	3 (5)‡
MSI
− (228)	70 (31)	40 (18)	70 (31)	106 (45)	58 (25)	16 (7)
+ (41)	28 (68)§	27 (66)§	30 (73)§	32 (77)§	29 (71)§	24 (59)§

*p<0.2; †p<0.1; ‡p<0.05; §p<0.005.

MSI, microsatelite instability.