Table 3.
Characteristics of microsatellite instability (MSI+) colorectal cancer with or without hMLH1 methylation
| hMLH1 (%) | |||
| Feature (n) | Unmethylated | Methylated | p Value |
| Total (54) | 10 (19) | 44 (81) | |
| Sex | |||
| Female (33) | 3 (9) | 30 (91) | |
| Male (21) | 7 (33) | 14 (67) | 0.035† |
| Age | |||
| <68 y (27) | 9 (33) | 18 (67) | |
| ≥68 y (27) | 1 (4) | 26 (96) | 0.005‡ |
| Site | |||
| Distal (4) | 2 (50) | 2 (50) | |
| Proximal (49) | 7 (14) | 42 (86) | 0.13† |
| Grade | |||
| Well/moderate (31) | 9 (29) | 22 (71) | |
| Poor (22) | 1 (5) | 21 (95) | 0.033† |
| TP53 | |||
| Wild-type (42) | 9 (21) | 33 (79) | |
| Mutant (8) | 1 (13) | 7 (87) | NS |
| K-ras | |||
| Wild-type (41) | 5 (12) | 36 (88) | |
| Mutant (8) | 4 (50) | 4 (50) | 0.028† |
| CpG methylation* | |||
| <2 sites (15) | 10 (67) | 5 (33) | |
| ≥2 sites (34) | 0 (0) | 34 (100) | <0.001† |
*p16, MDR1, and MINT-2.
†Fisher’s exact test.
‡χ2 test.