Time course of impairment by dyspepsia (A) and of the three most frequent individual dyspeptic symptoms severe enough to require treatment (B) from the beginning of the previous and during the present study. Values in (A) are medians (because of skewed distribution) of visual analogue scales (VAS) and those in (B) are percentage of patients who needed treatment for the given individual symptom. A significant (p<0.0001) improvement in all parameters was noted during the treatment period in the present study but no change occurred during follow up. There was no significant difference between the treatment groups. Intention to treat analysis. OM, omeprazole; OM+AMO, omeprazole plus amoxicillin. a, beginning of previous study; b, start of treatment in the present study; and c, end of treatment in the present study.