Table 1.

Interleukin 10 (IL-10) (−1082) polymorphism allele and genotype distribution

	IBS (n=230)		Controls (n=450)
	n	%	n	%
IL-10
Allele frequency§
−1082*G (high)	219	48*	438	52
−1082*A (low)	241	52	412	48
Genotype¶
G/G (high producer)	49	21†	135	32
G/A (intermediate)	121	53	168	39
A/A (low producer)	60	26	122	29
Genotype¶
A− (G/G)	49	21‡	135	32
A+ (A/A or G/A)	181	79	290	68

*Odds ratio (OR) 1.17 (95% confidence interval 0.93–1.49); p=0.097.

†Fewer irritable bowel syndrome (IBS) patients of high producer (G/G) genotype (χ²=11.97, df=2, p=0.003), with more patients carrying A allele (A+: G/A or A/A) (χ²=8.08, OR 1.72 (1.18–2.50), p=0.004)‡.

§n= number of alleles in each group, being twice the number of individuals as two alleles are inherited.

¶n=number of individuals with specific genotype.