Figure 2.

Cumulative percentage of relapse for the three therapies, corrected for the baseline factors pretreatment hepatitis B virus (HBV) DNA, alanine aminotransferase (ALT), sex, and race, can be calculated for a specific patient using the results of the Cox regression (the estimated relative risks and baseline hazard). Here, the risk is illustrated for a male Caucasian patient with a mean pretreatment HBV DNA level of 4×10⁸ g eq/ml after lamivudine (LAM), interferon (IFN), and IFN-lamivudine (IFN+LAM) combination therapy for three different ALT values: (A) ALT <2×upper limit of normal (ULN), (B) ALT 2–5×ULN, (C) >5×ULN. Relapse rates are particularly high in patients with a baseline ALT <2×ULN.