Table 3.

Relative risks (hazard rates) of relapse according to the multivariate analysis (Cox regression stratified by centre and correcting for sex, HBV DNA, ALT, and race)

Variable	HBeAg relapse		HBV DNA relapse
Variable	Relative risk (95% CI)	p Value (log likelihood)	Relative risk (95% CI)	p Value (log likelihood)
Therapy		0.01		0.01
IFN	1		1
LAM	4.6 (1.4–14.5)	0.01	3.9 (1.3–12.1)	0.02
Combination	0.7 (0.1–3.9)	0.72	0.6 (0.1–2.9)	0.50
Sex
Male	1		1
Female	0.4 (0.2–0.9)	0.04	0.5 (0.2–1.2)	0.12
Race
Caucasian	1		1
Asian	0.8 (0.3–2.4)	0.74	1.1 (0.4–3.0)	0.84
Log HBV DNA	1.61 (1.03–2.52)	0.03	1.7 (1.1–2.6)	0.02
ALT (×ULN)		0.03		0.05
≤2	1		1
2–5	0.4 (0.2–0.9)	0.02	0.4 (0.2–0.9)	0.03
≥5	0.3 (0.1–0.8)	0.01	0.4 (0.2–0.9)	0.03

IFN, interferon; LAM, lamivudine; HBV, hepatitis B virus; ALT, alanine aminotransferase; ULN, upper limit of normal.