Table 3.

Association testing based on the haplotype frequencies of A→G₁₃₆₄, A→C₂₆₀₇, and DEL₂₆₀₉

Group	n*	ln(L)	χ2	p†
Patients	91	−90.84	36.54	0.42
Controls	71	−97.86	21.99
All subjects	162	−192.24	56.49

*Number of individuals.

†The relevant test statistic is T= ln(L, cases) + ln(L, controls) − ln(L, cases+controls together). Twice this value has an approximate χ² distribution with a number of degrees of freedom (df) equal to the number of haplotypes estimated. For the above data: (−90.84) + (−97.86) − (−192.24) = 3.54; χ²=2×3.54 = 7.08 which on 7 df is associated with an empirical significance level of p=0.42.