Table 3.
Univariate Cox regression | Multivariate Cox regression | ||||||||||
Factor | Group | n | Events | p | HR | 95% CI of HR | p | HR | 95% CI of HR | ||
Resected | Resected | 280 | 37 | 1.00 | |||||||
Unresected | 82 | 11 | 0.11 | 1.75 | 0.88 | 3.47 | 0.06 | ||||
Site of primary tumour | Right sided | 82 | 13 | 1.00 | |||||||
Residual colon | 148 | 16 | 0.05 | 0.47 | 0.22 | 1.00 | 0.08 | ||||
Rectum | 130 | 19 | 0.42 | 0.75 | 0.37 | 1.52 | 0.35 | ||||
Sites of metastases* | Non-peri/oment | 295 | 34 | 1.00 | |||||||
Peri/oment | 67 | 14 | 0.007 | 2.35 | 1.26 | 4.40 | 0.04 | 1.98 | 1.03 | 3.82 | |
Age | Continuous | 362 | 48 | 0.002 | 0.96 | 0.93 | 0.99 | 0.001 | 0.96 | 0.93 | 0.98 |
Sex | Male | 229 | 29 | 1.00 | |||||||
Female | 133 | 19 | 0.60 | 1.17 | 0.66 | 2.08 | 0.67 | ||||
CEA | Continuous | 346 | 47 | 0.31 | 1.00 | 1.00 | 1.00 | 0.36 | |||
LDH | Continuous | 142 | 21 | 0.32 | 1.00 | 0.999 | 1.000 | — | |||
Hb | Continuous | 362 | 48 | 0.07 | 0.82 | 0.67 | 1.02 | 0.43 | |||
Alk phosph | Continuous | 359 | 48 | 0.46 | 1.00 | 0.999 | 1.002 | — | |||
Albumin | Continuous | 359 | 48 | 0.42 | 0.97 | 0.91 | 1.04 | — | |||
PS category | 0–1 | 273 | 38 | 1.00 | |||||||
2–4 | 83 | 9 | 0.60 | 1.22 | 0.59 | 2.53 | 0.48 |
*Presence of absence of peritoneal and/or omental metastases (peri/oment).
HR, Hazard ratio; CEA, carcinoembryonic antigen; LDH, lactate dehydrogenase; Hb, haemoglobin; Alk phosph, alkaline phosphatase; PS, performance status.