Table 2.

Histological colitis scoring system

Feature score	Score	Description
Inflammation severity	0	None
	1	Mild
	2	Moderate
	3	Severe
Inflammation extent	0	None
	1	Mucosa
	2	Submucosa
	3	Transmural
Crypt damage	0	None
	1	Basal 1/3 damage
	2	Basal 2/3 damage
	3	Crypt lost; surface epithelium present
	4	Crypt and surface epithelium lost
Per cent involvement	0	0%
	1	1–25%
	2	26–50%
	3	51–75%
	4	76–100%

Histological criteria to evaluate severity of inflammation. The score ranges from 0 to 14 (total score), which represents the sum of scores from 0 to 4 for severity and extent of inflammation, crypt damage, and per cent of the colon involved. All evaluations were performed by observers unaware of the treatment groups.