Table 4.

Familial predisposition of colorectal cancer (FHCRC) and other types of cancers (FHOC) among first degree relatives and risk of net growth of adenomas <10 mm followed up in situ three years after inclusion

			Crude OR (95% CI)		Adjusted OR (95% CI)¶
	Cases with net adenoma growth* (n)	Cases with no net adenoma growth† (n)	All‡	Placebo§	All‡	Placebo§	Adjusted OR (95% CI)** (All‡)	Adjusted OR (95% CI)†† (All‡)
FHCRC
No	22‡/13d§	51‡/28§	1.0	1.0	1.0	1.0	1.0	1.0
Yes	9/5	5/2	4.2 (1.3–13.9)	5.4 (0.9–31.5)	3.7 (1.1–12.5)	4.3 (0.7–26.5)	3.8 (1.1–12.8)	3.9 (1.2–13.4)
FHOC
No	19/13	31/16	1.0	1.0	1.0	1.0	1.0	1.0
Yes	12/5	25/14	0.8 (0.3–1.9)	0.4 (0.1–1.5)	0.7 (0.3–1.8)	0.3 (0.1–1.1)	0.7 (0.3–1.8)	0.9 (0.3–2.1)

*Net growth=more than 1 mm increase in total adenoma diameter after three years.

†No net growth=less than 1 mm increase in total adenoma diameter after three years; no detectable change or regression.

‡Data for the whole study group of 87 adenoma cases

§Data for the 48 adenoma cases who only received placebo during the three years of intervention.²⁷

¶Adjusted for smoking status.

**Adjusted for type of intervention and smoking status.

††Adjusted for type of intervention and number of polyps found at inclusion.