Figure 8 .

Effect of the dominant negative transforming growth factor β activated kinase 1 (dnTAK1) on gastrin induced nuclear factor κB (NFκB) activation. MKGR26 cells were transfected with pNFκB-LUC and control vector or a construct encoding the dominant negative mutant of TAK1. pRL-SV40 was cotransfected as an internal standard. After 24 hours they were treated with gastrin for eight hours and the luciferase assay was performed. The results are expressed as fold induction compared with control cells treated with vehicle alone. Values are means (SEM) from six independent (*p<0.05 v bar 1; †p<0.05 v bar 2).