Table 4 .

Clinical recurrence and outcome in the four patients in whom histological recurrence was diagnosed in protocol biopsies

Patient (OLT)	Delay post-OLT (y)	Liver enzyme titre (ALT (IU/l)) (N<43)	Autoantibody titre	Histological features	Treatment
51	15	1000	ANA=1:640, anti-SMA=1:160, anti-SLA−	Substantial portal inflammatory plasmocyte infiltration, moderate septal fibrosis	Switch to FK*
155	10	80	SMA=1:640, anti-SLA+	Substantial plasmocyte infiltration in portal tract	Higher dose resumption of steroid therapy
205	11	182	SMA=1:640, anti-SLA−	Moderate plasmocyte infiltration in portal tract	Higher dose resumption of steroid therapy
421	10	680	SMA=1:320, anti-SLA−	Substantial portal inflammatory plasmocyte infiltration, scant areas of lobular necrosis	Switch to FK* and retransplantation

FK, tacrolimus; OLT, orthotopic liver tranplantation; ALT, alanine aminotransferase; ANA, antinuclear antibodies; SMA, smooth muscle antibodies; SLA, soluble liver antigen.