Figure 2 .

Non-genomic inhibition of intermediate conductance basolateral K⁺ channels by aldosterone (ALDO). (A) Representative recordings from a cell attached patch containing multiple channels (holding voltage −40 mV, referenced to pipette interior; 140 mmol/l Na⁺ in bath, 145 mmol/l K⁺ in pipette), showing rapid onset of inhibition of K⁺ channel activity by 1 nmol/l aldosterone, with further inhibition after increasing the aldosterone concentration to 10 nmol/l. Dashed lines indicate zero current levels (C) and dotted lines open channel levels (1–4). (B) Summary of data from 7–11 cell attached patches.