Figure 4 .

Ethylisopropylamiloride (EIPA) prevented non-genomic inhibition of intermediate conductance basolateral K⁺ channels by aldosterone (ALDO). (A) Representative recordings from a cell attached patch containing multiple channels (holding voltage −40 mV, referenced to pipette interior; 140 mmol/l Na⁺ in bath, 145 mmol/l K⁺ in pipette) showing failure of 1–10 nmol/l aldosterone to inhibit K⁺ channel activity in the presence of 20 μmol/l EIPA, a specific Na⁺:H⁺ exchange inhibitor. Dashed lines indicate zero current levels (C) and dotted lines open channel levels (1, 2). (B) Summary of data from six cell attached patches.