Table 2.

Multipoint linkage analysis in two Finnish ICP pedigrees

	BSEP			MDR3			FIC1
Distance (cM)	D2S2190 (0.0)	2.40	D2S111 (4.80)	D7S644 (0.0)	1.45	D7S2410 (2.9)	D18S977 (0.0)	0.75	D18S849 (1.5)
LOD score family 1	−0.26	−0.23	−0.24	−1.09	0.43	0.73	−1.25	−1.24	−1.24
LOD score family 2	1.12	1.06	1.00	−1.38	−1.38	−1.40	−1.86	−1.86	−1.86
Total LOD score	0.86	0.83	0.76	−2.47	−0.95	−0.67	−3.11	−3.10	−3.10

ICP, intrahepatic cholestasis of pregnancy; BSEP, bile salt export pump gene; FIC1, familial intrahepatic cholestasis 1 gene; MDR3, multiple drug resistance 3 gene; LOD score, logarithm of odds score.

LOD scores were calculated using the Genehunter 2.0 version.